Ospreys start with wing Tom Williams and prop Ma’afu Fia for Saturday’s European Champions Cup opener at home to Munster.
Wales players Nicky Smith, Bradley Davies and Aled Davies are named on the bench after finishing World Cup duty.
There are five changes to the Munster side that beat Ulster in the Pro14.
Keith Earls, Tyler Bleyendaal, Conor Murray, Jeremy Loughman and Tommy O’Donnell all come into the starting side.
Munster have won four out of five of the Champions Cup meetings between the two sides.
Ospreys’ only success was in the two sides’ last encounter in December 2010, edging it 19-15.
Munster have also bossed the encounters in the Pro14, winning five out of six games including a 28-12 victory at home against Ospreys last month.
The inclusion of Williams and Fia are the only two starting changes from the Ospreys side beaten at home by Southern Kings in the Pro14 last weekend.
That result – a first away success for the South African side – prompted Ospreys head coach Allen Clarke to admit his side were “in a dark period”.